4/13 10:00_花田耕介教授_Lineage-Specifically Emerged Genes in Plant Evolution
(Evolutionary Genetics and Genomics)
時間：2023. 04. 13 Thu. 10:00
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Japan
講題：Lineage-Specifically Emerged Genes in Plant Evolution
During the course of plant evolution, genomes acquire novel genetic elements as sources of functional diversities. Recent advance of next generation sequencing revealed much of lineage-specifically emerged genes such as duplicated genes, de-novo alternative splicing isoforms and de-novo small coding genes in plant genomes. However, lineage-specifically duplicated genes might keep redundant functions with original ones. Also, de-novo alternative splicing isoforms and small genes are expressed as RNA, but the RNA products might be just transcription errors. Therefore, I’m trying to identify lineage-specific genes inducing phenotypic diversities in plants. I mainly used the best model organism of plants (Arabidopsis thaliana) to understand the adaptive evolution throughout lineage-specifically emerged genes. First, I collected various omics data such as transcriptome, proteome, metabolome, interactome, phenome, etc in A. thaliana (Evaluation). Throughout the integration of these omics by bioinformatics analysis, I tried to infer recently emerged genes causing phenotypic changes in evolution (Study & Design). Then, I examined the functional roles of inferred genes by transgenic plants (Construction). This strategy (Evaluation→Study→Design→Construction) is useful to understand the molecular mechanisms of target genes. Here, as sources of phenotypic diversities, I will introduce the evolution of phenotypic variation by three types of newly emerged genes such as gene duplication, alternative splicing isoforms, and small genes (Figure 1).