(Evolutionary Genetics and Genomics)

Time：2024. 06. 18  Tue. 10:30

Venue: Auditorium, 1st Floor, Interdisciplinary Research Building

Speaker：Dr. Chih-Kuan Chen
                     Research Associate
                     Keck School of Medicine, Dept. of Pathology, University of Southern California

Title：Conserved Regulatory Switches for the Transition from Natal Down to Juvenile Feather in Birds

Host：Dr. Meiyeh Jade Lu

Abstract
        The transition from natal downs for heat conservation to juvenile feathers for simple flight is a remarkable environmental adaptation process in avian evolution. However, the underlying epigenetic mechanism for this primary feather transition is mostly unknown. Here we conducted time-ordered gene co-expression network construction, epigenetic analysis, and functional perturbations in developing feather follicles to elucidate four downy-juvenile feather transition events. We report that extracellular matrix reorganization leads to peripheral pulp formation, which mediates epithelial-mesenchymal interactions for branching morphogenesis. α-SMA (ACTA2) compartmentalizes dermal papilla stem cells for feather renewal cycling. LEF1 works as a key hub of Wnt signaling to build rachis and converts radial downy to bilateral symmetry. Novel usage of scale keratins strengthens feather sheath with SOX14 as the epigenetic regulator. We show that this primary feather transition is largely conserved in chicken (precocial) and zebra finch (altricial) and discuss the possibility that this evolutionary adaptation process started in feathered dinosaurs.

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