人員 研究人員 王達益 副研究員

王達益 副研究員

實驗室主持人

Dr.王達益

副研究員

國立台灣海洋大學博士, 1999

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辦公室: 跨領域 A303

電話:+886-2-2787-2271
研究領域
  • 多源基因體
  • 演化基因體

研究方向

  • 1.建構微生物群落網路
    物種間的交互作用是了解生物演化及生態地位的重要依據，微生物群落是生物中最複雜的組織之一，加上大部分的菌種無法在實驗室培養，因此微生物的相關研究極具挑戰性。隨著次世代定序的發展，多源基因體學成為探索微生物世界的重要工具。多源基因體學藉由高通量的DNA解序與分析，能夠直接獲得環境中微生物菌相進而分析不同環境間的歧異度。我們利用這個資訊，研究微生物的交互作用並建立網路關係。藉由形成的網路，可以了解物種間的競爭、合作、寄生及生態地位等議題。最終，我們期待能預測整個微生物菌相的動態變化，並進一步以生物技術改造微生物群落。
  • 2.基因調控因子之演化
    ENCODE計畫在生物研究引起廣大的注意，研究中提到基因體中有很高的比例被轉錄但是沒有進一步轉譯成胺基酸。這些未轉譯RNA其實在基因調控扮演重要角色，也吸引各國學者紛紛投入龐大的資源進行研究，我們注意到其中一種antisense RNA，很可能是利用與mRNA互補的關係進行基因表現的調控。酵母菌可以進行基因改造，是一種常用的模式物種，我們利用酵母菌研究antisense RNA的生成，演化並探討可能的作用機制。

 

最新發表

期刊論文 ( 2016 - 2021 )

  1. Le MH, Wang D, 2020, “Structure and membership of gut microbial communities in multiple fish cryptic species under potential migratory effects.”, Scientific reports, 10(1), 7547. (SCIE) (IF: 3.998; SCIE ranking: 23.9%) Link
  2. Brandon-Mong Guo-Jie, Shaw Grace Tzun-Wen, Chen Wei-Hsin, Chen Chien-Chang, Wang Daryi, 2020, “A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model”, BMC Microbiology, 20(1). (SCIE) (IF: 2.989; SCIE ranking: 49.3%) Link
  3. Chen Cheng-Yu, Chen Chih-Kuan, Chen Yi-Ying, Fang Andrew, Shaw Grace Tzun-Wen, Hung Chih-Ming, Wang Daryi, 2020, “Maternal gut microbes shape the early-life assembly of gut microbiota in passerine chicks via nests”, Microbiome, 8(1). (SCIE) (IF: 11.607; SCIE ranking: 5.9%) Link
  4. Shaw, G.T.W., Weng, C.Y., Chen, C.Y., Weng, F.C.H., Wang, D.*, 2019, “A systematic approach re-analyzing the effects of temperature disturbance on the microbial community of mesophilic anaerobic digestion.”, SCIENTIFIC REPORTS, 10.1038/s41598-019-42987-0. (SCIE) (IF: 3.998; SCIE ranking: 23.9%)
  5. Tan TK, Low VL, Ng WH, Ibrahim J, Wang D, Tan CH, Chellappan S, Lim YAL, 2019, “Occurrence of zoonotic Cryptosporidium and Giardia duodenalis species/genotypes in urban rodents.”, Parasitology international, 69, 110-113. (SCIE) (IF: 1.866; SCIE ranking: 52.6%) Link
  6. Low VL, Takaoka H, Adler PH, Tan TK, Weng FC, Chen CY, Lim YAL, Ya'cob Z, Chen CD, Sofian-Azirun M, Wang D, 2018, “A novel molecular and chromosomal lineage of the anthropophilic Simulium (Simulium) rufibasis subgroup (Diptera: Simuliidae) in Taiwan.”, Parasitology research, 117(10), 3137-3143. (SCIE) (IF: 1.641; SCIE ranking: 60.5%) Link
  7. Weng, F.C.H., Shaw, G.T.W., Weng, C.Y., Yang, Y.J., Wang, D.*, 2017, “Inferring Microbial Interactions in the Gut of the Hong Kong Whipping Frog (Polypedates megacephalus) and a Validation Using Probiotics”, FRONTIERS IN MICROBIOLOGY, 8, 525-526. (SCIE) (IF: 4.236; SCIE ranking: 25%) Link
  8. Chen CY, Chen PC, Weng FC, Shaw GT, Wang D, 2017, “Habitat and indigenous gut microbes contribute to the plasticity of gut microbiome in oriental river prawn during rapid environmental change.”, PloS one, 12(7), e0181427. (SCIE) (IF: 2.74; SCIE ranking: 38%) Link
  9. Shaw GT, Liu AC, Weng CY, Chou CY, Wang D, 2017, “Inferring microbial interactions in thermophilic and mesophilic anaerobic digestion of hog waste.”, PloS one, 12(7), e0181395. (SCIE) (IF: 2.74; SCIE ranking: 38%) Link
  10. Weng Francis Cheng-Hsuan, Yang Yi-Ju, Wang Daryi*, 2016, “Functional analysis for gut microbes of the brown tree frog (Polypedates megacephalus) in artificial hibernation”, BMC Genomics, 17(S13), 31-42. (SCIE) (IF: 3.594; SCIE ranking: 27.6%,32%) Link
  11. Shaw Grace Tzun-Wen, Pao Yueh-Yang, Wang Daryi*, 2016, “MetaMIS: a metagenomic microbial interaction simulator based on microbial community profiles”, BMC Bioinformatics, 17(1), 2-6. (SCIE) (IF: 3.242; SCIE ranking: 15.3%,37.2%,31.2%) Link